Rabies is a zoonotic disease (a disease that is transmitted to humans from animals) that is caused by a virus called rhabdovirus that causes acute encephalitis (inflammation of the brain) in endotherms. Rabies virus, a rhabdovirus present in infected animal’s saliva is inoculated into the bite wound. This disease infects domestic and wild animals, and is spread to people through close contact with infected saliva via bites or scratches. For a human, rabies is almost invariably fatal if post exposure prophylaxis is not administered prior to the onset of severe symptoms. The rabies virus infects the central nervous system, ultimately causing disease in the brain and death. Once the rabies virus reaches the central nervous system and symptoms begin to show, the infection is effectively untreatable and usually fatal within days. Once symptoms of the disease develop, rabies is nearly always fatal.